| Annotated protein: | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Phosphatase and tensin homolog). Gene symbol: PTEN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O54857 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTEN |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Knafo S, et al. "PTEN recruitment controls synaptic and cognitive function in Alzheimer's models" Nat Neurosci. 2016 Mar;19(3):443-53 PMID:26780512 |
| Figure(s): | Fig. 6 |
| Annotation description: | Neurons expressing the WT EGFP-PTEN show localization in dendritic spines. 29/5/2017 Pim - Importantly, over-expressed EGFP-PTEN shows stimulus-dependent translocation into spines. This shows this is not an over-expression artifact. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | Upon activation of the NMDA-R, PTEN translocates from the post-synaptic cytosol into the PSD, as shown by immuno-EM (Fig. 4). @ PMID:20628354 |
| SynGO annotation ID: | 497 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |