Annotated protein:Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan). Gene symbol: LRP4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8VI56
antibody wiki:
SynGO gene info:SynGO data @ LRP4
Ontology domain:Cellular Component
SynGO term:synapse (GO:0045202)
Synapse type(s):hippocampus
Annotated paper:Gomez AM, et al. "Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4" Elife. 2014 Nov 19;3:e04287 PMID:25407677
Figure(s):Figure 6
Annotation description:Figure 6: biochemical fractionation of mouse hippocampi showed LRP4 was enriched in the synaptic membrane fraction. LRP4 knockout controls confirmed antibody specificity.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Biochemical fractionation (generic)
Western blot
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:4967
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology