| Annotated protein: | Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (120 kDa lysosomal membrane glycoprotein) (LGP-120) (CD107 antigen-like family member A) (CD antigen CD107a). Gene symbol: LAMP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P14562 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LAMP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Scheefhals N, et al. "Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5" Cell Rep. 2019 Oct 8;29(2):258-269.e8 PMID:31597090 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1a-b: authors developed an assay to image the surface expressed pool of mGluR5 (GRM5) in live cells and observe agonist-induced mGluR5 internalization in dendritic spines of hippocampal neurons. Figure 1c-d: internalized mGluR5 puncta overlapped with the lysosomal marker GFP-LAMP1 (LAMP1: 31% ± 5%) |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4966 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |