| Annotated protein: | BTB/POZ domain-containing protein KCTD8. Gene symbol: KCTD8. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q50H33 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCTD8 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic membrane (GO:0042734) |
| Annotated paper: | Bhandari P, et al. "GABA(B) receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals" Elife. 2021 Apr 29;10:e68274 PMID:33913808 |
| Figure(s): | Figure 3c, 7c-d |
| Annotation description: | - K+-channel tetramerization domain-containing proteins (KCTDs) are auxiliary GABAB receptor (GBR) subunits. - Experiments were performed at the synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN). -Using pre-embedding immunogold labelling, imaged with TEM, KCTD8 showed some localization at the active zone membrane whereas the majority was localized at the presynaptic plasma membrane at more than 50nm from active zone (Fig. 3c). - Absence of KCTD12b leads to an increased presence of KCTD8 at active zone (Fig. 7) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Robin Clement Guus Smit Matthijs Verhage |
| ORCID: | 0000-0002-2286-1587 0000-0002-2514-0216 |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4949 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |