| Annotated protein: | Autophagy protein 5 (APG5-like). Gene symbol: ATG5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99J83 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ATG5 |
| Ontology domain: | Biological Process |
| SynGO term: | axonal transport (GO:0098930) |
| Synapse type(s): | glutamatergic |
| Annotated paper: | Negrete-Hurtado A, et al. "Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons" Nat Commun. 2020 Mar 24;11(1):1535 PMID:32210230 |
| Figure(s): | Fig 2, 3, 4 |
| Annotation description: | ATG5 and ATG16L1 are well known to be involved in LC3 lipid conjugation which is essential for autophagosome formation. Here authors show that ATG5 (and also ATG16L1) are involved in the regulation of axonal microtubuli and transport of axonal cargo. In accordance with this, ATG5 KO cells and ATG16L1 KO cells show axonal dwellings in cortical axons that are mostly located at presynaptic sites (Fig. 2, 3) and a reduction of microtubuli dynamics (Fig. 4). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Western blot unlisted assay type |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 4946 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |