| Annotated protein: | Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362). Gene symbol: SDC2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P34900 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SDC2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse maturation (GO:0090128) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Ethell IM, et al. "Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons" J Cell Biol. 1999 Feb 8;144(3):575-86 PMID:9971750 |
| Figure(s): | Fig. 6,7 |
| Annotation description: | "Forced expression of syndecan-2 in young hippocampal neurons induces the morphological maturation of dendritic spines" (Fig. 6). "Cytoplasmic domain of syndecan-2, but not COOH-terminal PDZ binding motif, is required for the targeting of syndecan-2 to dendritic spines" (Fig. 7). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4940 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |