| Annotated protein: | Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1). Gene symbol: CADPS. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80TJ1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CADPS |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle priming (GO:0016082) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jockusch WJ, et al. "CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins" Cell. 2007 Nov 16;131(4):796-808 PMID:18022372 |
| Figure(s): | Fig.1 |
| Annotation description: | CAPS-1 is essential for synaptic vesicle priming. Isolated, autaptic hippocampal neurons deficient for CAPS-1 as well as CAPS-1 and -2 exhibit reduced evoked neurotransmitter release, spontaneous release and readily-releasable pool size in response to hypertonic sucrose application, without a change in the vesicular release probability. 12/5/2017 Pim - The "regulation of..." box not checked because CAPS1 is shown to be "Essential Synaptic Vesicle Priming Proteins" (see title of referenced paper). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 494 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |