| Annotated protein: | Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB). Gene symbol: MMP9. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P50282 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MMP9 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor diffusion trapping (GO:0150054) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Michaluk P, et al. "Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin beta1 signaling" J Neurosci. 2009 May 6;29(18):6007-12 PMID:19420267 |
| Figure(s): | Fig. 1 |
| Annotation description: | Proteolytic activty of MMP9 can increase the mobility of NMDA receptors in synapses, as detected by tracking of QD-labelled anti-NMDAR antibody. Application of inactive recombinant MMP9 (E402A) does not enhance mobility (Fig. 1D,E). Effect is mediated through integrin beta-1 signaling. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Optical physiology |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4937 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |