| Annotated protein: | Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB). Gene symbol: MMP9. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P50282 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MMP9 |
| Ontology domain: | Biological Process |
| SynGO term: | modification of synaptic structure, modulating synaptic transmission (GO:0099564) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Wang XB, et al. "Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately" Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19520-5 PMID:19047646 |
| Figure(s): | Fig. 1, Fig. 2 |
| Annotation description: | Theta burst-triggered LTP induces spine enlargement that is prohibited by inhibition of MMP9 (Fig. 1). Brief local puffing of MMP9 on naive spines induces potentiation and volume increase of spines. This is not the case when using inactive MMP9 (Fig. 2). MMP-9 drives integrin-dependent cofilin phosphorylation in dendritic spines (Fig. 4). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Two-photon microscopy Whole-cell patch clamp |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | This paper confirms the influence of active MMP9 on dendritic spine morphology at CA1 synapses. @ PMID:21896646 |
| SynGO annotation ID: | 4936 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |