| Annotated protein: | Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB). Gene symbol: MMP9. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P50282 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MMP9 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wilczynski GM, et al. "Important role of matrix metalloproteinase 9 in epileptogenesis" J Cell Biol. 2008 Mar 10;180(5):1021-35 PMID:18332222 |
| Figure(s): | Fig. 2Q-V, Fig. 3L |
| Annotation description: | Immunogold-electronmicroscopy shows goldparticles within dendritic spines and in the synaptic cleft (ticket #4931) (Fig. 2Q-V). "Within MMP-9 - immunoreactive spines, immunogold particles were present mainly in the spine head, frequently being located adjacent to, or within, postsynaptic densities (PSD) of axospinous (excitatory) synapses (Fig. 2, Q, R, T, and U)." Fig. 3L,M shows massively enhanced MMP9 immunoreativity in spines 72hrs after treatment with kainate. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4930 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |