| Annotated protein: | Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1). Gene symbol: CADPS. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80TJ1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CADPS |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic dense core vesicle exocytosis (GO:0099525) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Farina M, et al. "CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons" Elife. 2015 Feb 26;4:e05438 PMID:25719439 |
| Figure(s): | Fig. 3 and Fig. 4 |
| Annotation description: | CAPS-1 mediates dense core vesicle fusion in neurons. CAPS-1 and -2 deletion reduces dense core vesicle fusion in response to electrical stimulation in neurons from hippocampal mass cultures (Fig. 3) and isolated, autaptic cultures (Fig. 4) from synapses, but also extra-synaptic sites. Live-imaging (pHluorin) experiments. 12/5/2017 Pim: -Fig.3 shows CAPS1/2 double KO animals, but in Fig.4 it is shown that in hippocampal neurons CAPS1 is specifically involved. Therefore, no IGI of CAPS1/2 is needed. -based on data on SVs CAPS1 is though to mediate one of the steps of LCDV exocytosis (docking, priming, release) and therefore the "regulates..." box was not selected. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Optical physiology |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 493 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |