| Annotated protein: | Muscarinic acetylcholine receptor M1. Gene symbol: CHRM1. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: P56489 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRM1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | cerebral cortex, glutamatergic cerebral cortex, GABAergic |
| Annotated paper: | Galvin VC, et al. "Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex" Neuron. 2020 May 20;106(4):649-661.e4 PMID:32197063 |
| Figure(s): | Figure 2A-C |
| Annotation description: | Figure 2: muscarinic M1 receptor (M1R, gene CHRM1) DAB immunolabeling in the primate dorsolateral prefrontal cortex showed localization at dendritic spines, putative GABAergic postsynapses, dendrites and astrocytes (Fig. S2). The omission of the primary antibody or substitution with non-immune serum abolished all reactivity. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Robin Clement Guus Smit Matthijs Verhage |
| ORCID: | 0000-0002-2286-1587 0000-0002-2514-0216 |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4914 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |