| Annotated protein: | Potassium voltage-gated channel subfamily Q member 2. Gene symbol: KCNQ2. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: F7ASD7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNQ2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Galvin VC, et al. "Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex" Neuron. 2020 May 20;106(4):649-661.e4 PMID:32197063 |
| Figure(s): | Figure 6G-H |
| Annotation description: | Figure 6G-H: KCNQ2 immunogold labeling in the primate dorsolateral prefrontal cortex showed localization at dendritic spines and dendrites. The omission of the primary antibody or substitution with non-immune serum abolished all reactivity. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Robin Clement Guus Smit Matthijs Verhage |
| ORCID: | 0000-0002-2286-1587 0000-0002-2514-0216 |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4911 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |