| Annotated protein: | Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362). Gene symbol: SDC2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P34900 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SDC2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse assembly (GO:0051963) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lin YL, et al. "Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway" J Cell Biol. 2007 Jun 4;177(5):829-41 PMID:17548511 |
| Figure(s): | Fig. 1, Fig.10 A,B |
| Annotation description: | "Syndecan-2 is important for dendritic spine formation". Knockdown with shRNA reduces formation of protrusions from dendrites (Fig. 1). Syndecan-2 positive protrusion opposed by structures contained the presynaptic marker synaptophysin (Fig. 10A). Syndecan-2 acts via neurofibromin-Ena/VASP signaling pathway on dendritic spinogenesis (Fig. 10) |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | This paper shows the cooperation of EphB2 and Syndecan-2 in dendritic spine morphogenesis. "Syndecan-2 Clustering and the Syndecan-2-Induced Spine Formation Require Tyrosine Phosphorylation by EphB2" (Fig. 4). @ PMID:11580899 |
| SynGO annotation ID: | 4904 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |