| Annotated protein: | Autophagy protein 5 (APG5-like). Gene symbol: ATG5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99J83 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ATG5 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Overhoff M, et al. "Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse" EMBO J. 2022 Nov 17;41(22):e110963 PMID:36217825 |
| Figure(s): | Fig. 7 |
| Annotation description: | Autophagy-dependent PKA signaling regulates synaptic GLUR1 localization and AMPAR function (Fig. 7). Conditional KO of ATG5 leads to increased GluR1 levels (panel C,D,E). ATG5 cKO causes increased Ca2+ signals (K) that are blocked by CNQX (L). Amplitude (S) and frequency (T) of AMPAR sEPSC is increased in pyramidal KO neurons to the WT. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Optical physiology Electrophysiology (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4902 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |