| Annotated protein: | NAD(+) hydrolase SARM1 (NADase SARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and TIR motif-containing protein 1). Gene symbol: SARM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6PDS3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SARM1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse disassembly (GO:1905806) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Osterloh JM, et al. "dSarm/Sarm1 is required for activation of an injury-induced axon death pathway" Science. 2012 Jul 27;337(6093):481-4 PMID:22678360 |
| Figure(s): | Fig. 4C |
| Annotation description: | The study shows that in the absence of SARM1 disassembly of motorneuron presynapses and Wallerian degeneration after axotomy does not occur (or is significantly delayed). Similar observations were made for fly neuromucular junctions. Interestingly, SARM1 -/- axons are not protected from nerve growth factor (NGF) withdrawl-induced axonal degeneration (Fig. S5). |
| Evidence tracking, Biological System: | Cultured neurons Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4897 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |