| Annotated protein: | NAD(+) hydrolase SARM1 (NADase SARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and TIR motif-containing protein 1). Gene symbol: SARM1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZUM2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SARM1 |
| Ontology domain: | Biological Process |
| SynGO term: | modification of postsynaptic structure (GO:0099010) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Chen CY, et al. "Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology" J Cell Biol. 2011 May 16;193(4):769-84 PMID:21555464 |
| Figure(s): | Fig. 5 |
| Annotation description: | "Sarm1 knockdown also influenced the number and morphology of dendritic spines in mature neurons. In Sarm1 knockdown neurons, mushroom-shaped or stubby dendritic spines were still present, but with lower density along dendrites (Fig. 5A and B). We noticed that the remaining dendritic spines in Sarm1 knockdown neurons are longer and that their spine heads are larger compared with those in neurons transfected with vector control (Fig. 5, A and B). These data suggest that Sarm1 also influences the density and morphology of dendritic spines." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 4896 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |