| Annotated protein: | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]. Gene symbol: CASP3. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70677 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CASP3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | D'Amelio M, et al. "Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease" Nat Neurosci. 2011 Jan;14(1):69-76 PMID:21151119 |
| Figure(s): | FIgure 4B-C |
| Annotation description: | Figure 4B: Cleaved caspase-3 is shown to be present in hippocampal synaptosome preparations, but not in total hippocampal homogenates, shown by an immunoblot. Figure 4C: Immuno-EM shows caspase-3-immunopositive postsynaptic compartments in CA1 dendritic spines. The immunoprecipitates were specifically concentrated in the PSD. No immunoreactivity was found in cell soma, nuclei, presynaptic terminals or surrounding glial projections. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) Electron Microscopy |
| Annotator(s): | Robin Clement Guus Smit Matthijs Verhage |
| ORCID: | 0000-0002-2286-1587 0000-0002-2514-0216 |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | This article contains biochemical fractionation data showing Caspase-3 expression in the PSD in control and AD human patient tissue, as well as tentative immunohistochemical data. @ PMID:18818379 |
| SynGO annotation ID: | 4890 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |