| Annotated protein: | Guanine nucleotide-binding protein G(o) subunit alpha. Gene symbol: GNAO1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P59215-2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GNAO1 |
| Ontology domain: | Cellular Component |
| SynGO term: | synaptic vesicle membrane (GO:0030672) |
| Synapse type(s): | Parallel fibre (cerebellum -> Purkinje-cell) |
| Annotated paper: | Pahner I, et al. "Functional G-protein heterotrimers are associated with vesicles of putative glutamatergic terminals: implications for regulation of transmitter uptake" Mol Cell Neurosci. 2003 Jul;23(3):398-413 PMID:12837624 |
| Figure(s): | Figure 3 |
| Annotation description: | Figure 3b: Immunoelectron microscopic detection of synaptophysin and G protein α-subunits in parallel fiber synapses of the rat cerebellum. Immunogold signals for Gαo2 (gene GNAO1, isoform Gαo2) and Gαq/11 concentrate in the vesicle cluster of the presynaptic terminals. Individual immunogold-labeled SSVs are indicated by arrowheads. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | identified in SV fraction of rat brain proteome at high abundance, but not enriched as compared to P2 @ PMID:33376223 identified in SV fraction of rat brain proteome; NP_059023 @ PMID:17110340 |
| SynGO annotation ID: | 4874 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |