| Annotated protein: | Regulator of G-protein signaling 4. Gene symbol: RGS4. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: A0A5F8ANU0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RGS4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | Paspalas CD, et al. "Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex" Cereb Cortex. 2009 Sep;19(9):2145-55 PMID:19153107 |
| Figure(s): | Figure 6 |
| Annotation description: | Figure 5, S3: immunogold EM imaging of RGS4 protein in macaque prefrontal cortex showed localization to dendritic spines. RGS4 in distal dendrites was directly associated with synapses. "Synapse-associated particles were separated by 15-35 nm from the postsynaptic membrane, and rarely were embedded in the postsynaptic density (PSD) per se. Note that the label is distributed across from both central and peripheral portions of the synaptic disk, and involves asymmetric and to a lesser extent symmetric axodendritic synapses, exemplified in Figure 5A,C, respectively. Seventy-six percent of RGS4-labeled axodendritic synapses were type I, asymmetric junctions (see Table 2). However, RGS4 expression in type II, symmetric synapses could be underestimated as we excluded synapses captured at oblique planes, and those that could not be unequivocally categorized in a single section." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4873 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |