| Annotated protein: | Regulator of G-protein signaling 4. Gene symbol: RGS4. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: A0A5F8ANU0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RGS4 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | Paspalas CD, et al. "Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex" Cereb Cortex. 2009 Sep;19(9):2145-55 PMID:19153107 |
| Figure(s): | Figure 7 |
| Annotation description: | Figure 7: immunogold EM imaging of RGS4 protein in macaque prefrontal cortex showed localization to the presynapse, albeit sparingly. "Glut-like axons establishing axodendritic and axospinous synapses (arrowheads) displayed low expression of RGS4 and minimal axoplasmic labeling". Regarding subcellular localization; "presynaptic active zones were not labeled". |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4872 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |