Annotated protein:	Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17). Gene symbol: CAMK2G. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P11730
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SynGO gene info:	SynGO data @ CAMK2G
Ontology domain:	Cellular Component
SynGO term:	postsynaptic cytosol (GO:0099524)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	He X, et al. "A Critical Role for gammaCaMKII in Decoding NMDA Signaling to Regulate AMPA Receptors in Putative Inhibitory Interneurons" Neurosci Bull. 2022 Aug;38(8):916-926 PMID:35290589
Figure(s):	Figure 4
Annotation description:	Figure 4: Immuno-gold labeling of γCaMKII (CAMK2G) in the dendritic shaft is near postsynaptic synapses of cultured hippocampal neurons. Following stimulation with 30 μmol/L NMDA, co-localization of CAMK2G and PSD95 (DLG4) is increased. "A remarkable feature of γCaMKII expression is that it is highly enriched in inhibitory interneurons (e.g., parvalbumin-positive neurons), with relatively fewer excitatory neurons in the hippocampus and cortex (PMID:33548174)." Authors used immunofluorescence imaging to corroborate this by co-staining alpha- and gamma-CaMKII in cultured hippocampal neurons, and observed: "We found strong expression of γCaMKII in αCaMKII-negative neurons, which had few spines and were likely interneurons (Fig. 3C, D)".
Evidence tracking, Biological System:	Cultured neurons
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Electron Microscopy
Annotator(s):	Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	4857
Dataset release (version):	20231201
View annotation as GO-CAM model: