| Annotated protein: | General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein). Gene symbol: TAMALIN. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9JJA9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TAMALIN |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Pandey S, et al. "The post-synaptic scaffolding protein tamalin regulates ligand-mediated trafficking of metabotropic glutamate receptors" J Biol Chem. 2020 Jun 19;295(25):8575-8588 PMID:32376687 |
| Figure(s): | Figure 7 |
| Annotation description: | Figure 7: Tamalin knockdown did not have any effect on the surface expression of GluA1-containing receptors. Chemically induced mGluR-mediated AMPAR endocytosis was disrupted after shRNA knockdown of Tamalin, rescued by WT Tamalin but not by mutated Tamalin where its S-SCAM (gene MAGI2) interaction site was disabled. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | original characterization of S-SCAM (synaptic scaffolding molecule, gene = Magi2) @ PMID:9694864 |
| SynGO annotation ID: | 4856 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |