| Annotated protein: | Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha). Gene symbol: RABEP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O35551 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RABEP1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Oueslati Morales CO, et al. "Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons" Traffic. 2021 Dec;22(12):454-470 PMID:34564930 |
| Figure(s): | Figure 6 |
| Annotation description: | Figure 6:"cLTD treatment induced a significant decrease in GluA1 intensity within the synaptic areas both upon EGFP and Rabaptin-5 wt overexpression but not in Rabaptin-5 S407A expressing neurons (Figure 6A,B). Our data thus provide evidence that phosphorylation of Rabaptin-5 at serine 407 regulates basal and activity-induced AMPAR endocytosis most probably downstream of PKD." Author summary of presented data; "PKD is activated downstream of NMDA and AMPA receptor signaling and promotes AMPAR endocytosis probably via regulating Rab5 activity through Rabaptin-5" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4855 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |