| Annotated protein: | Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (120 kDa lysosomal membrane glycoprotein) (LGP-120) (CD107 antigen-like family member A) (CD antigen CD107a). Gene symbol: LAMP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P14562 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LAMP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Annotated paper: | Goo MS, et al. "Activity-dependent trafficking of lysosomes in dendrites and dendritic spines" J Cell Biol. 2017 Aug 7;216(8):2499-2513 PMID:28630145 |
| Figure(s): | Figure 1, 2 |
| Annotation description: | Figure 1, 2: Lysosomes marked by LAMP1 and LysoTracker were both identified in postsynaptic spines of dissociated hippocampal cultures. Furthermore, this was confirmed with APEX2 (Fig. 3). "We found lysosomes not only in the cell body and dendrites (Fig. 1 E) but also in dendritic spines (Fig. 1, F and G). Upon quantification, ~7% of spines have a lysosome in the head of the spine (Fig. 1 H)." Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4849 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |