| Annotated protein: | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (24KG). Gene symbol: RAB11A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62494 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAB11A |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle endosomal processing (GO:0099532) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Kokotos AC, et al. "Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11" Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10177-E10186 PMID:30301801 |
| Figure(s): | Figure 6 |
| Annotation description: | Figure 6: When activity-dependent TMR-dextran uptake was assessed in these neurons, mCer-Rab11Q70L (constitutively active form) significantly increased the number of nerve terminals performing activity-dependent bulk endocytosis (ADBE) (Fig. 6C). In contrast, all of the other Rab mutants had no effect (Fig. 6C). Authors conclude; "We found that Rab11Q70L increased the number of nerve terminals performing ADBE. This effect was not due to increased SV exocytosis, since Rab11Q70L did not impact on this parameter. Rab11Q70L preferentially localizes to nerve terminals, as does endogenous Rab11 (SI Appendix, Fig. S13)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4846 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |