| Annotated protein: | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (CD antigen CD71). Gene symbol: TFRC. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q99376 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TFRC |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic recycling endosome membrane (GO:0099063) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Park M, et al. "Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes" Neuron. 2006 Dec 7;52(5):817-30 PMID:17145503 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1: Recycling endosomes localize to postsynaptic spines (immunoEM, Fig. 1d). Immunofluorescence imaging shows TfR (Transferrin receptor protein 1), a marker for recycling endosomes, at postsynapses (Fig. 1b,c). This is confirmed by immunogold EM of adult rat CA1 hipocampus (Fig. 1f). Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 1d; internalized mGluR5 strongly co-localizes with TfR @ PMID:31597090 |
| SynGO annotation ID: | 4845 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |