| Annotated protein: | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (24KG). Gene symbol: RAB11A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62494 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAB11A |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic endosome (GO:0098830) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Kokotos AC, et al. "Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11" Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10177-E10186 PMID:30301801 |
| Figure(s): | Figure 1, 2, 5, 6 |
| Annotation description: | Figure 1, 2, table 1: RAB11 was identified in biochemical enrichment of neuronal endosomes. Figure 5, 6: immunofluerescence imaging showed RAB11 co-localized with presynaptic marker proteins, constitutively active Rab11 (Rab11Q70L) was recruited to nerve terminals and facilitates activity-dependent bulk endocytosis. Authors concluded that "Rab11Q70L preferentially localizes to nerve terminals, as does endogenous Rab11 (SI Appendix, Fig. S13)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal Biochemical fractionation (generic) Mass-spectrometry |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4844 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |