| Annotated protein: | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N). Gene symbol: EPB41L1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9WTP0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EPB41L1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | Parallel fibre (cerebellum -> Purkinje-cell) |
| Annotated paper: | Douyard J, et al. "Differential neuronal and glial expression of GluR1 AMPA receptor subunit and the scaffolding proteins SAP97 and 4.1N during rat cerebellar development" J Comp Neurol. 2007 May 1;502(1):141-56 PMID:17335044 |
| Figure(s): | Figure 6, 7, 8 |
| Annotation description: | Figure 6, 8: postembedding immunogold labeling of climbing fiber synapses localized protein 4.1N (EPB41L1) to the PSD from E19 until P7, while at later timepoints it was associated with intracellular organelles, the cytoskeleton, and the plasma membrane. Protein 4.1N could also be detected presynaptically. Figure 7: Protein 4.1N (and SAP97/DLG1) colocalized with GluR1 (GluA1/GRIA1) in Purkinje cells at early ages. Protein 4.1N (EPB41L1), a neuronal homolog of protein 4.1R, associates with actin cytoskeleton (PMID:10414974, PMID:11604393). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | original characterization of protein 4.1N (EPB41L1) @ PMID:10414974 Binding of CASK to the cytosolic domain of neurexin mediates binding of protein 4.1N (EPB41L1) and is paralleled by assembly of actin microfilament. CASK, Protein 4.1, and Actin/Spectrin filaments are in the same protein complex @ PMID:11604393 |
| SynGO annotation ID: | 4827 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |