| Annotated protein: | Cofilin-1 (Cofilin, non-muscle isoform). Gene symbol: CFL1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P18760 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CFL1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Racz B, et al. "Spatial organization of cofilin in dendritic spines" Neuroscience. 2006;138(2):447-56 PMID:16388910 |
| Figure(s): | Figure 2, 3, 4 |
| Annotation description: | Figure 2: immunofluorescence confocal imaging showed Cofilin in apposition to puncta of presynaptic marker VGLUT1, suggesting postsynaptic localization for Cofilin. Figure 3: Electron micrograph showing immunoperoxidase staining for cofilin in CA1. Figure 4: Immunogold labeling for cofilin in stratum radiatum of CA1. Authors conclude that "cofilin is localized to the PSD and the spine shell, and avoids the spine core". |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4821 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |