| Annotated protein: | Noelin (1B426B) (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) (Pancortin). Gene symbol: OLFM1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62609 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ OLFM1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696) |
| Annotated paper: | Pandya NJ, et al. "Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors" Cell Rep. 2018 Jul 31;24(5):1218-1230 PMID:30067977 |
| Figure(s): | Figure 5, 6, 7 |
| Annotation description: | Noelin1 interacts with the AMPAR with high affinity (Figure 1,2), co-localizes with APMAR at the PSD in cultured hippocampal neurons (Figure 4), but does not affect AMPAR rise- and decay time nor desensitization properties (Figure 3). Figure 5: chemical LTP induced in DIV21 primary neurons resulting in increased levels of synaptic AMPAR (surface GluA2/GRIA2) and Noelin1. Authors conclude; "Noelin1 expression is regulated in an activity-dependent manner and, therefore, might have a role in the accumulation and stabilization of synaptic AMPA receptors at the PSD." Figure 6, S6, 7: Single-particle tracking shows that Noelin1 reduces lateral mobility of both synaptic and extra-synaptic GluA1-containing receptors and affects short-term plasticity. While the ECM does not constrain the synaptic pool of AMPARs and acts only extrasynaptically, Noelin1 contributes to synaptic potentiation by limiting AMPAR mobility at synaptic sites. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4820 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |