| Annotated protein: | Membrane-associated protein Hem (dHem-2). Gene symbol: HEM. Taxonomy: Drosophila melanogaster (Fruit fly). Uniprot ID: P55162 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NCKAP1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse organization (GO:0050807) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Schenck A, et al. "WAVE/SCAR, a multifunctional complex coordinating different aspects of neuronal connectivity" Dev Biol. 2004 Oct 15;274(2):260-70 PMID:15385157 |
| Figure(s): | Fig. 6A |
| Annotation description: | Dlg immunofluorescence on larval neuromuscular junction shows abnormality in synaptic boutons upon Kette mutations. Kette is 60% homologous to human NCKAP1 and 48% homologous to NCKAP1L, as assessed by BLAST. Thus it is the likely ortholog of the NCKAP1 proteins. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | Nc46 immunofluorescence in Neuromuscular Junction show defects in synaptic boutons upon Kette mutations (Fig. 4) @ PMID:15269173 |
| SynGO annotation ID: | 482 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |