| Annotated protein: | Noelin (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) (Pancortin). Gene symbol: OLFM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88998 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ OLFM1 |
| Ontology domain: | Cellular Component |
| SynGO term: | extrinsic component of postsynaptic density membrane (GO:0099147) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Pandya NJ, et al. "Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors" Cell Rep. 2018 Jul 31;24(5):1218-1230 PMID:30067977 |
| Figure(s): | Figure 1, 2, 4 |
| Annotation description: | Figure 1,2: IPs, surface plasmon resonance and crosslinking showed that Noelin1 (OLFM1) interacts directly with GluA2 (GRIA2). Figure 4: STED imaging in DIV21 cultured hippocampal neurons showed Noelin1 (OLFM1) co-localized with GluA2 (GRIA2) and Homer1 at the PSD. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution Protein-protein interaction (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4819 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |