Annotated protein:	SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11). Gene symbol: SLITRK5. Taxonomy: Homo sapiens (Human). Uniprot ID: O94991
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SynGO gene info:	SynGO data @ SLITRK5
Ontology domain:	Biological Process
SynGO term:	synapse adhesion between pre- and post-synapse (GO:0099560)
Synapse type(s):	hippocampus
Annotated paper:	Yim YS, et al. "Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases" Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4057-62 PMID:23345436
Figure(s):	Figure 4
Annotation description:	Figure 2: Overexpression of Slitrk5 promoted excitatory synapse formation. Figure 3: Knockdown of Slitrk5 reduced synapse numbers in cultured hippocampal neurons. Figure 4: SLITRKs interact with PTPRs (Slitrk5 was not tested in the annotated paper due to lack of suitable antibodies, but was tested in PMID:26004511). Authors conclude; "Although the precise mechanism governing synaptic adhesion between Slitrks and LAR-RPTPs remains elusive, the fact that Slitrks and LAR-RPTPs serve double duty as inducers of either excitatory or inhibitory synapses places these protein families at center stage in the control of excitatory-inhibitory balance, which is critical for neuronal function (34)."
Evidence tracking, Biological System:	Cultured neurons Non-neuronal tissue
Evidence tracking, Protein Targeting:	Over-expression
Evidence tracking, Experiment Assay:	Confocal
Annotator(s):	Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
Additional literature:	Figure 2: PTPδ and TrkB compete for binding to Slitrk5 @ PMID:26004511
SynGO annotation ID:	4806
Dataset release (version):	20231201
View annotation as GO-CAM model: