| Annotated protein: | SLIT and NTRK-like family, member 5. Gene symbol: SLITRK5. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: M0R9U3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLITRK5 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | striatum, glutamatergic |
| Annotated paper: | Shmelkov SV, et al. "Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice" Nat Med. 2010 May;16(5):598-602, 1p following 602 PMID:20418887 |
| Figure(s): | Figure 4 |
| Annotation description: | Figure 4: Immunostaining of primary striatal rat neurons, infected with Flag-Slitrk5 lentivirus and transfected with PSD95 fused to mCherry, showed co-localization of Slitrk5 and PSD95 (DLG4) in synaptic puncta. Resolution of imaging was too low to further elucidate subcellular localization. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4803 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |