| Annotated protein: | Tyrosine-protein kinase RYK (EC 2.7.10.1) (Kinase VIK) (Met-related kinase) (NYK-R). Gene symbol: RYK. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q01887 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RYK |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Feng B, et al. "Planar cell polarity signaling components are a direct target of beta-amyloid-associated degeneration of glutamatergic synapses" Sci Adv. 2021 Aug 18;7(34):eabh2307 PMID:34407949 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1B and movie S4: superresolution microscopy (3D-STORM) showed that Ryk colocalized with both presynaptic marker Bassoon and postsynaptic marker PSD-95. Signal for this antibody is much weaker than other proteins shown in this figure, but the images and movie shown in S4 together are suggestive of the model proposed by authors in Figure 1C. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. As also depicted by authors in Figure 1C. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4802 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |