| Annotated protein: | Cadherin EGF LAG seven-pass G-type receptor 3. Gene symbol: CELSR3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q91ZI0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CELSR3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Feng B, et al. "Planar cell polarity signaling components are a direct target of beta-amyloid-associated degeneration of glutamatergic synapses" Sci Adv. 2021 Aug 18;7(34):eabh2307 PMID:34407949 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1B: superresolution microscopy (3D-STORM) showed that Celsr3 colocalized with both presynaptic marker Bassoon and postsynaptic marker PSD-95. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. As also depicted by authors in Figure 1C. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4800 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |