| Annotated protein: | Vang-like protein 2 (Loop-tail protein 1) (Loop-tail-associated protein) (Van Gogh-like protein 2). Gene symbol: VANGL2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q91ZD4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ VANGL2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse disassembly (GO:1905806) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Feng B, et al. "Planar cell polarity signaling components are a direct target of beta-amyloid-associated degeneration of glutamatergic synapses" Sci Adv. 2021 Aug 18;7(34):eabh2307 PMID:34407949 |
| Figure(s): | Figure 1, 2, 4 |
| Annotation description: | "knocking out Vangl2 in the adult hippocampus led to a 27% increase of synapse numbers 2 months later. Furthermore, our results showed that Aβ oligomers were unable to cause synapse loss when Vangl2 was conditionally knocked out in vitro or in vivo in the adult hippocampus. PCP signaling is known to be mediated by a set of dynamic protein-protein interactions. One such essential interaction is an asymmetric intercellular complex composed of Frizzled and Celsr3 (17). We show that Vangl2 may disassemble glutamatergic synapses by disrupting the Celsr3/Frizzled3-Celsr3 intercellular complex." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Celsr3 promotes synapse assembly whereas Vangl2 inhibits assembly @ PMID:28057866 |
| SynGO annotation ID: | 4796 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |