| Annotated protein: | Prickle-like protein 2. Gene symbol: PRICKLE2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80Y24 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRICKLE2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Annotated paper: | Ban Y, et al. "Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex" Sci Adv. 2021 Oct 8;7(41):eabh2974 PMID:34613779 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1: superresolution microscopy (3D-STORM) showed that both PK1 (Prickle1) and PK2 (Prickle2) were predominantly colocalized with the postsynaptic marker, PSD-95, but not with the presynaptic marker, Bassoon (Fig. 1A and movies S1 to S4). "Although we were not able to pinpoint the exact information of how PK1 and PK2 are colocalized in synapses, we conclude that there is a considerable overlap of the distribution of PK1 and PK2 in synapses." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4789 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |