| Annotated protein: | Ankyrin-3 (ANK-3) (Ankyrin-G). Gene symbol: ANK3. Taxonomy: Mus musculus (Mouse). Uniprot ID: G5E8K5-3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ANK3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Annotated paper: | Yoon S, et al. "Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome" Mol Psychiatry. 2021 Jun;26(6):1775-1789 PMID:33398084 |
| Figure(s): | Figure 2 |
| Annotation description: | Figure 2: ANK3 (ankyrin-G) co-localizes with Homer1b/c at postsynaptic densities of mouse primary cortical cultured neurons. Furthermore, ankyrin-G (ANK3) 190kDa, but not 270kDa, robustly coimmunoprecipitated with Homer1b/c in PSD-enriched fractions (Fig. 2b). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4786 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |