| Annotated protein: | Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Zinc finger DHHC domain-containing protein 17). Gene symbol: ZDHHC17. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80TN5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ZDHHC17 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic Golgi apparatus (GO:0150051) |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | Huang K, et al. "Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins" Neuron. 2004 Dec 16;44(6):977-86 PMID:15603740 |
| Figure(s): | Figure 3B, 3C and 3G |
| Annotation description: | A peptide antibody coupled with immunogold labelling shows staining in dendrite and spines (Figure 3). Major staining at the Golgi apparatus by EM and fluorescence co-localization in other figures. Localization at dendritic Golgi is probably more common. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Vincent O'Connor (ORCID:0000-0003-3185-5709) |
| Lab: | Biological Sciences, Institute for Life Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom |
| Additional literature: | HIP14 presynaptic localization and function in Drosophila @ PMID:18158335 HIP14 protein is enriched in the brain, shows partial co-localization with htt in the striatum, and is found in medium spiny projection neurons, the subset of neurons affected in HD. HIP14 localizes to the Golgi, and to vesicles in the cytoplasm. @ PMID:12393793 HIP14 seems to be localized to dendritic Golgi and sporadically at synapses, which may explain why authors of this paper checked for synaptic localization and found none; "Endogenous HIP14 in these neurons does not colocalize with either a presynaptic protein marker, synaptophysin, or a postsynaptic protein marker, PSD95, which suggests that HIP14 is absent from synapses" @ PMID:19299482 |
| SynGO annotation ID: | 4782 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |