| Annotated protein: | Voltage-dependent calcium channel subunit alpha-2/delta-2 (Protein ducky) (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]. Gene symbol: CACNA2D2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6PHS9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CACNA2D2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696) |
| Synapse type(s): | striatum, GABAergic |
| Annotated paper: | Geisler S, et al. "Presynaptic alpha(2)delta-2 Calcium Channel Subunits Regulate Postsynaptic GABA(A) Receptor Abundance and Axonal Wiring" J Neurosci. 2019 Apr 3;39(14):2581-2605 PMID:30683685 |
| Figure(s): | Figure 8 |
| Annotation description: | Figure 8: Presynaptic overexpression of CACNA2D2 (α2δ-2 Calcium Channel) induces upregulation of postsynaptic GABAARs in striatal medium spiny neurons "First, using distinct experimental paradigms, we show here that α2δ-1 and α2δ-3, which both enhance excitatory synaptic transmission and increase presynaptic release probability (Hoppa et al., 2012), do not induce postsynaptic clustering of synaptic GABAAR subtypes. Second, the effect of α2δ-2 is independent of the presynaptic neurotransmitter identity, thus providing compelling evidence for a trans-synaptic function. Third, solely α2δ-2 splice variants lacking exon 23 specifically induced the recruitment of postsynaptic GABAARs opposite glutamatergic nerve terminals. Fourth, the effect of α2δ-2 is restricted to transfected synapses, emphasizing a synapse-specific role rather than a global alteration of GABAergic postsynaptic components." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4780 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |