| Annotated protein: | Early endosome antigen 1. Gene symbol: EEA1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BL66 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EEA1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic early endosome (GO:0098842) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Oueslati Morales CO, et al. "Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons" Traffic. 2021 Dec;22(12):454-470 PMID:34564930 |
| Figure(s): | Figure 3 |
| Annotation description: | Figure 3: immunofluorescence staining and confocal microscopy showed early endosome marker protein EEA1 was localized to dendrites but, to a lesser extend, also at and near dendritic spines in cultured hippocampal neurons. EEA1 localization to spines, as well as co-localization of GluA1 and EEA1 (anywhere in dendrites/spines), was increased upon stimulus. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4771 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |