| Annotated protein: | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1. Gene symbol: AGAP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A0A0G2K847 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AGAP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic endosome (GO:0098845) |
| Annotated paper: | Arnold M, et al. "The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin" Front Cell Neurosci. 2016 Sep 22;10:218 PMID:27713690 |
| Figure(s): | Figure 2, 3 |
| Annotation description: | Figure 2: AGAP1 is enriched in synaptosomal biochemical fractions, but co-localizes with synaptic marker proteins at only 15% of puncta in confocal fluorescence microscopy of cultured hippocampal neurons. Figure 3: Strong co-localization with AP3 showed AGAP1 localized to endosomal compartments in dendrites in E18 hippocampal neurons. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4766 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |