| Annotated protein: | AP-2 complex subunit alpha. Gene symbol: AP2A1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZUY8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AP2A1 |
| Ontology domain: | Cellular Component |
| SynGO term: | synaptic vesicle (GO:0008021) |
| Annotated paper: | Taoufiq Z, et al. "Hidden proteome of synaptic vesicles in the mammalian brain" Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596 PMID:33376223 |
| Figure(s): | Dataset S1 |
| Annotation description: | AP2A1 was detected in SV biochemical fractions, and enriched as compared to the P2 fraction. This protein was also detected in SV biochemical fractions in Takamori et al. 2006 (PMID: 17110340). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) Mass-spectrometry |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | XP_218624 protein was identified in SV biochemical fractions @ PMID:17110340 immuno-EM showed with an antibody against AP2A1/2 showed localization to pre- and post-synapse in rat hippocampal neurons @ PMID:15322548 |
| SynGO annotation ID: | 4758 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |