Annotated protein:Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2). Gene symbol: SLC18A2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q01827
antibody wiki:
SynGO gene info:SynGO data @ SLC18A2
Ontology domain:Cellular Component
SynGO term:integral component of synaptic vesicle membrane (GO:0030285)
Synapse type(s):striatum, dopaminergic
ventral tegmental area, dopaminergic
Annotated paper:Nirenberg MJ, et al. "Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine" J Neurosci. 1996 Jul 1;16(13):4135-45 PMID:8753875
Figure(s):6 A and 6 C
Annotation description:Immunogold highlighting distribution in neuronal sub-compartments. Selected figures show synaptic vesicle and dense core vesicle in presynaptic compartment as judged by juxtaposition to the PSD.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Noa Lipstein (ORCID:0000-0002-0755-5899)
Cordelia Imig (ORCID:0000-0001-7351-8706)
Vincent O'connor (ORCID:0000-0003-3185-5709)
Nils Brose (ORCID:0000-0003-0938-8534)
Lab:Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany
Additional literature:Antibody sensitivity and selectivity determined by western blot and pre-absorption with immunizing antigen. @ PMID:7666200
SynGO annotation ID:474
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology