| Annotated protein: | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Micromolar-calpain) (muCANP). Gene symbol: CAPN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P97571 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CAPN1 |
| Ontology domain: | Biological Process |
| SynGO term: | protein catabolic process at postsynapse (GO:0140249) |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | Wang Y, et al. "Distinct roles for mu-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration" J Neurosci. 2013 Nov 27;33(48):18880-92 PMID:24285894 |
| Figure(s): | Figure 2, 6, 8 |
| Annotation description: | Figure 2: Synaptic NMDAR-dependent calpain activation degrades PHLPP1 and activates Akt and ERK1/2 pathway. (rat brain P2 fraction, purified μ-calpain = CAPN1, calpain 1) Figure 6: A μ-calpain-specific inhibitor blocks synaptic NMDAR-induced PHLPP1 degradation but not extrasynaptic NMDAR induced neurotoxicity. Figure 8: μ-calpain but not m-calpain (CAPN2, calpain 2) is recruited to synaptic NMDAR complex following synaptic NMDAR activation. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Western blot |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4738 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |