| Annotated protein: | Clathrin light chain A (Lca). Gene symbol: CLTA. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P08081 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CLTA |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic endocytic zone (GO:0098843) |
| Annotated paper: | Catsburg LA, et al. "Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses" Elife. 2022 Jan 24;11:e74387 PMID:35072626 |
| Figure(s): | Figure 1, 3, 7 |
| Annotation description: | Confocal, STED (Figure 1) and STORM (Figure 3) microscopy showed GFP-CLCa (clathrin light-chain-A, CLTA) and Homer1 are adjacently localized at dendritic spines. Taken together, results showed CLCa is localized at the postsynaptic endocytic zone (Figure 7). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Super resolution Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4722 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |