| Annotated protein: | Metabotropic glutamate receptor 7 (mGluR7). Gene symbol: GRM7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35400 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRM7 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Bodzeta A, et al. "Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions" Mol Biol Cell. 2022 Jul 1;33(8):ar66 PMID:35511883 |
| Figure(s): | Figure 1, S1, 2, S2 |
| Annotation description: | Figure 1c,d,e: Super-resolution imaging of hippocampal neuronal cultures showed anti-mGluR7 (GRM7) co-localized with Bassoon (BSN). Figure 2,S2: Fluorescence recovery after photobleaching (FRAP) experiments showed surface-expressed mGluR7 was immobile and enriched in presynaptic boutons. A model for mGluRs 2 and 7 is proposed in Figure 6. Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Super resolution Fluorescence recovery after photobleaching (FRAP) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4721 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |