Annotated protein:Calmodulin-3. Gene symbol: CALM3. Taxonomy: Mus musculus (Mouse). Uniprot ID: P0DP28
antibody wiki:
SynGO gene info:SynGO data @ CALM3
Ontology domain:Biological Process
SynGO term:presynaptic endocytosis (GO:0140238)
Synapse type(s):Calyx of Held
Annotated paper:Jin YH, et al. "Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses" J Neurosci. 2019 Nov 27;39(48):9478-9490 PMID:31628181
Figure(s):6C-H, Figure 7C-K
Annotation description:Experiments use bioassays of endocytosis following stimulated exocytosis in calyx of held and hippocampal synapses in face of a Calmodulin 2 selective knockdown. The summed data supports a role for CaM2 in the efficient recycling of synaptic vesicles and in promoting access to the readily releasable pool. There are clear effects in face of Calmodulin 2 knockout despite evidencing residual levels of calmodulin accounted for by Calmodulin 1 and 3 expression (See Figure 6B and 7A and 7B).

Based on the presynaptic expression of calmodulins from the Calm3 gene and the identical protein sequences generated from Calm1-3, this annotation infers that Calm3 has a similar presynaptic function as Calm2.
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Over-expression
Evidence tracking, Experiment Assay:Electron Microscopy
Whole-cell patch clamp
Optical physiology
Non-tracable Author Statement (NAS):This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors.
Annotator(s):Vincent O'Connor (ORCID:0000-0003-3185-5709)
Lab:Biological Sciences, Institute for Life Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom
SynGO annotation ID:4717
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology